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Understand pain
  • Overview
  • Why pain matters
  • Pain treatment options
  • Pain FAQ

The problem with pain

Pain is a deeply personal experience, shaped by a complex interplay of physical, emotional, and situational factors. For millions, it’s more than a fleeting discomfort—it’s a constant presence that disrupts daily life. A 2022 study published in Pain revealed that over 20% of Americans—roughly 50 million adults—live with chronic pain, underscoring the scale and impact of this issue.

Pain feels different for everyone

Pain doesn’t affect everyone the same way. What feels manageable to one person may be overwhelming to another. This is because pain is as unique as the individual experiencing it. Genetic differences can influence how pain is perceived, tolerated and treated. Some people are naturally more sensitive to pain, while others may respond differently to medications. These factors highlight the importance of personalized pain management strategies that address each patient’s unique needs.

Changing the trajectory of the opioid epidemic

For too long, opioids have been the default solution to postsurgical and chronic pain. Addressing the opioid epidemic starts with understanding pain, the gateway to opioid use and moving to reimagine pain relief. The opioid epidemic has roots in postsurgical overprescription, with leftover medications often leading to misuse and addiction. Reducing the need for opioid use after surgery can significantly lower the risk of new opioid use disorders and prevent unused prescriptions from posing a danger to families and communities.

The risks of dependency have created additional barriers, as fear of pain and addiction often deters people from pursuing necessary, life-changing surgeries. For those with chronic pain, the cycle of opioid reliance brings its own set of challenges, highlighting the urgent need for safer, sustainable approaches to pain relief. Ending opioid reliance requires education, advocacy and patient empowerment.

The management of pain is critical. It starts pre-surgery, should be intraoperative and continued afterwards.

Dr. Paul Sethi
Orthopedic surgeon
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EXPAREL® (bupivacaine liposome injectable suspension), ioverao, ZILRETTA® (triamcinolone acetonide extended-release injectable suspension), and Pacira are registered trademarks of the respective subsidiaries of Pacira BioSciences, Inc. All other trademarks referenced herein are the property of their respective owners.


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